Using a powerful new in vivo model of neuronal ageing within the Drosophila brain, you will characterise the harmful changes that neurons undergo at the subcellular level during ageing, and unravel the cascade of events that cause them, with a focus on intracellular degradation systems and the upstream regulatory pathways. You should have a Ph. The post is available from 1st of September until 31st of August Shaw Research is seeking postdoctoral fellows of exceptional ability to join our New York—based team.
This is a unique opportunity to develop and work with transformative technology in a dynamic, interdisciplinary environment.
Candidates should have expertise in computational, theoretical, or quantum chemistry, theoretical chemical physics, applied mathematics, or in a relevant area of computer science.
Relevant areas of experience might include force field improvement through detailed comparisons of simulation data with NMR measurements or other experimental data, development and implementation of new methodology, such as integrators or efficient approximations of long-range forces, methods for enhanced sampling or free-energy calculations, or tools to efficiently analyze large simulation datasets.
Specific knowledge of any of these areas is less critical, however, than outstanding intellectual ability, unusually strong research skills, and a history of innovation and accomplishment. We are committed to fostering a stimulating, rewarding, and flexible work environment, and we offer above-market compensation to candidates of truly exceptional ability.
To submit an application, please use the link provided below: Shaw Research is an independent research group that is pursuing an ambitious, long-term strategy aimed at fundamentally transforming the process of drug discovery. We have developed a special-purpose supercomputer capable of executing molecular dynamics MD simulations orders of magnitude faster than was previously possible.
Our current projects include investigations of proteins and other biomedically relevant macromolecules as well as the development of computational chemistry methods to enable more accurate and effective MD simulations.
Shaw Research is an equal opportunity employer, dedicated to the goal of building a diverse workforce. We welcome inquiries from all exceptionally well-qualified applicants, regardless of race, color, gender, age, religion, national origin, sexual orientation, gender identity, disability, pregnancy, marital status, military service eligibility, veteran status, or status in any other category protected by law.
The project will leverage isogenic cell lines and genome-wide RNAi and CRISPR lentiviral libraries to explore the functional interconnections of the Fanconi pathway with the rest of the cell. The project is part of a collaboration with the clinical team operating the French National Reference Center for Fanconi Anemia. The 2-year fellowship is funded by Genopole and is intended to French or other applicants who obtained either their master degree or their PhD in France, are currently working abroad and are willing to return in France to pursue their career.
The post holder will carry out statistical analysis of large human cohort datasets related to intergenerational effects of metabolic disease and cognitive function. Successful applicants will hold a PhD in Statistics or Biostatistics and have relevant experience. Preference will be given to applicants with a background in neuroscience or metabolic disorders. Candidates should have expertise in computational biophysics or chemistry, structural biology, drug discovery, or in a relevant area of computer science.
Relevant areas of experience might include direct application of molecular dynamics or other computational methods to drug discovery, investigation of allosteric interactions or other functionally important conformational changes in biological molecules, structure prediction or design for proteins or RNA, study of protein—protein or protein—nucleic acid interactions, or study of fundamental biophysical problems, such as protein and RNA folding.
The project is wide-ranging from protein biochemistry to single molecule data collection and analysis. This project will be undertaken in collaboration with partners and will require travel in the UK and possibly beyond. This interdisciplinary project is aimed at understanding how inhibitors of transcription factor proto-oncogenes work. By directly imaging of RNA polymerase moving along DNA, we will learn how inhibitors exert their action and using this information we can work with the Mason group at the University of Bath to generate better inhibitors.
We have fully developed the technology to visualise six fluorophores in wide-field microscopy simultaneously, enabling us to image multiple components acting together. In addition, the inhibitor selection assay is fully developed at the University of Bath. This is a hugely valuable project, for which training and support will be given throughout, including regular meetings between team members and a 6-week exchange programme with the University of Bath to gain new skills and enhance progress The Kad lab is very well-equipped with microscopes dedicated to single molecule fluorescence imaging, dark-field and laser tweezers.
In addition, the School of Biosciences at Kent houses numerous shared facilities from NMR and Mass Spectrometry to cell biology and super-resolution imaging. For more information or informal enquiries please contact Dr.
The successful candidate will develop new or advanced research skills and competences in translational cancer biology. They will collaborate with Pfizer scientists in Dublin and at the Center for Therapeutic Innovation CTI , San Francisco, with the goal of validating a potential drug candidate that can advance into clinical testing.
The position is based University College Dublin and involves undertaking a specific research programme under the direction and supervision of the PI. In vivo experience with cancer mouse models is required. Excellent oral and written communication skills is also essential.
This position may be appointed at either UCD Post-Doctoral Research Fellow Level 1 or Level 2 depending on the relevant qualifications and experience of the successful candidate.
Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of UCD are unable to accept late applications. Prior to application, further information including application procedure should be obtained from the UCD Job Vacancies website: Any CV's submitted by Recruitment Agencies will be returned. The project is three years in duration with funding renewed annually subject to satisfactory progress.
The lab focusses on the molecular mechanisms underlying cancer development, The project will focus on development and characterisation of a novel mouse model for studying a family of deoxycytidine deaminase enzymes APOBEC3 which have been implicated in generating somatic mutations that drive cancer development and resistance to therapy.
You will be working as part of a dynamic group within the School of Biosciences at the University of Kent and in close collaboration with our co-investigators at Imperial College London, the University of Cambridge and the Institute for Cancer Research. The School offers a supportive and nurturing environment for post-doctoral research. The applicant will need a PhD in an appropriate field, and in particular, will need experience working with laboratory mice.
They will have the ability to work independently, efficiently, creatively and collegially, and to co-supervise graduate students. They will possess strong written and oral communication skills and be highly self-motivated. This is an exciting opportunity to play an important role on a cutting-edge project investigating the way that laws influence our decisions to engage or not to engage in environmentally compliant behaviour in Europe. You will be the postdoctoral researcher on the project, and will form part of an interdisciplinary international team of six people, comprising Professor Kingston, 3 Ph.
The project, which has been running since , is now entering the data analysis phase, and the successful candidate will have particular responsibility for helping to analyse the data collected, including by means of statistical regression analysis, and also data collected from surveys and interviews. The successful candidate will also help to design the final part of the project which employs behavioural economics techniques.
UCD do not require assistance from Recruitment Agencies. Any CVs submitted by Recruitment Agencies will be returned. Prior to application, further information including application procedure should be obtained from the Work at UCD website: The objectives of this research are to understand how CAVs will affect road transport in Ireland and to identify what needs to be done now in order to maximise the opportunities that CAVs will bring.
The focus of the research will be divided into three strands: Candidates should refer to www. The applicant will undertake analyses of over 15, HIV genomes and associated epidemiological data, developing state-of-the-art statistical models and tools to advance this goal.
Candidates will have a PhD in a relevant field computational biology, computer science, mathematical biology or statistics , will have expertise in phylodynamics, molecular evolution or phylogenetic epidemiology of viruses, strong skills in computational biology, statistics or sequence data analysis and an interest in infectious disease research in a public health context. The candidates will have a track-record of publishing in peer-reviewed, academic journals and excellent communication skills.
The post is full-time until October Please include a CV and supporting statement with details of how you meet the knowledge, skills and experience required. Informal enquiries to Prof. As a core support facility, NMR spectroscopy contributes to a large range of projects, including protein complexes, membrane proteins, protein dynamics and interaction studies.
NMR often complements other structural X-ray crystallography, cryoEM and biophysical methods through collaboration. Preference will be given to those who have experience of working in a collaborative and multidisciplinary environment. For informal discussions please contact Stefan Freund: UKRI is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.
Director of Ageing DivisionSalary: Dublin or Belfast, but the successful candidate will be expected to travel between both our offices and throughout Ireland North and South in the delivery of this role. Summary of main duties: Working at a strategic level this is focused on translating research, data, policy and practice relevant to public health and ageing.
The translation function means drawing on a range of data, research reports and analysis and turning these into formats that are usable by policy makers, professionals and practitioners. It also involves scanning trends, policies and practice to identify key issues for research on ageing and inequalities. To translate data, research, policy and practice relevant to public health and ageing into multiple formats that will be accessible, usable and actable by decision-makers and the policy community.
To advise on development, implementation and evaluate the impact of Government programmes and policy. To undertake evidence syntheses to inform decision-making processes including guideline development relating to ageing and public health. To undertake primary and secondary policy and practice focused research qualitative and quantitative relating to ageing and public health.
To undertake periodic analysis of policies, literature and frameworks local, national, EU and international relevant to demographic change, ageing and public health. To produce user-accessible articles, reports and briefings on key public health and ageing issues. To convene events and build strong working relationships with key stakeholders: To make presentations to key audiences in the area of public health and ageing.
To work collaboratively to help improve population health in Ireland North and South. To raise awareness and understanding of the connection between poverty and determinants of health inequalities as well as demographic ageing and public health.
To represent IPH on relevant groups, bodies and events and contribute to the promotion of the organisation across stakeholders. To undertake other duties as may be assigned from time to time by your line manager. The above is not an exhaustive list of duties and you will be expected to perform different tasks as necessitated within the organisation and the overall business plan. Philippe Campeau focuses on studying new skeletal dysplasias, new forms of epilepsy and chromatin remodeling disorders www.
We identify new disease-causing genes, understanding the pathological basis of disease, and try to improve the management of children affected by these conditions. The tasks of the trainees will be to analyze exome and genome data to identify causative mutations. In vitro, the effect of the mutations on the gene's pathway will be assessed by a combination of analysis of RNA, protein and cell studies.
Applicants should have extensive molecular biology experience in research labs, and provide simply a CV and university transcripts to Dr. The successful candidate will join a very active inter-disciplinary group in the Centre for Computational Science, and will work on providing guiding theoretical principles and computational methods for the design of novel materials based on their atomic composition and structure.
The post-holder will work primarily on scientific applications of HemeLB, a flexible lattice-Boltzmann code for the simulation of blood flow in support of medical and clinical decision making and for physiological research. The postholder will be expected to engage closely in the development of software within the project, including contributions to the verification, validation and uncertainty quantification toolkit which will be a central output of VECMA.
The post is funded by the European Commission and is available from 15 June or soon thereafter, for a period of 24 months initially.