In the beginning, Knoxville appeared mostly in commercials and made several minor appearances as an extra. When the "big break" he sought eluded him, he decided to create his own opportunities by writing and pitching article ideas to various magazines.
An idea to test self-defense equipment on himself captured the interest of Jeff Tremaine 's skateboarding magazine Big Brother , and the stunts were filmed and included in Big Brother's "Number Two" video. Jackass TV series Knoxville is responsible for many of the ideas in Jackass, and is often seen as the de facto leader of the crew.
With help from Tremaine's friend, film director Spike Jonze , they pitched a series to various networks. A deal was made with MTV and Jackass was born. Prior to Jackass premiering on MTV, Knoxville and company turned down an offer to perform their stunts for Saturday Night Live on a weekly basis,  though Knoxville later hosted a episode of the show. He starred in Jackass: He played a two-headed alien in the film Men in Black II. He starred in Katrina Holden Bronson 's Daltry Calhoun in , and in The Ringer as an office worker who pretends to be disabled and joins the Special Olympics to pay for surgery for his office's janitor.
He starred in the movie Lords of Dogtown as Topper Burks, made a minor appearance in the movie Coyote Ugly , and was featured as a guest voice on two episodes of King of the Hill. Knoxville appeared in the John Madden -directed adaptation of Elmore Leonard 's novel, Killshot , however his character was subsequently removed from the final cut of the film.
He voiced himself in an episode of Family Guy. The videos focus on the resurgence of creativity in Detroit. Knoxville voiced Leonardo in the film, Teenage Mutant Ninja Turtles  but did not appear in the sequel.
Derek Freda formally announced the formation of a new production company called 'Hello Junior', which will continue Knoxville's now-longstanding relationship with Paramount Pictures , who have signed an exclusive two-year first-look deal with Knoxville and 'Hello Junior' in the wake of the massive success of Bad Grandpa in late Knoxville was quoted as saying, "I am over the damn moon about continuing an amazing partnership with Paramount Pictures," he said.
I am glad I will be doing it for Paramount. They have a daughter, Madison born After eleven years of marriage, the couple separated in July Knoxville filed for divorce on July 3, He said this was done by "sticking a tube into his penis all the way up to his bladder ", referring to the practice of urinary catheterization.
Knoxville said the process prevented scar tissue from forming  and performed the procedure "twice a day for three and a half years" after the injury.